Scientist I, Medicinal Chemistry

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Research organization as a Scientist I, Medicinal Chemistry. This individual contributor role will work as a key member of an integrated, multidisciplinary drug discovery team making significant contributions toward the discovery of important new drug candidates.

Responsibilities:

• Design and synthesis of biologically active compounds to support SAR:

  • Analysis of biological data.

  • SBDD based design of analogs.

  • Planning and execution of the synthetic routes, synthesis purification of final targets.

• Recommend alternative synthetic routes, research new methods and techniques, and proactively seek out others to identify solutions to challenges.

• Present research findings to the Medicinal Chemistry team and management.

• Partner in the scientific activities of other outstanding medical chemists and cross functional team members and create an environment where all ideas are shared.

• Collaboration with external teams, CROs (contract research organizations).

Required Skills, Experience and Education

• D. with a background in synthetic organic chemistry and 0-3 years of postdoctoral or relevant pharma/biotech industry experience.

• Strong understanding of synthetic organic and medicinal chemistry.

• Experience with NMR, HPLC, and Mass Spectrometry techniques.

• Familiar with modern synthetic, organic chemistry techniques and instrumentation.

• Well versed in synthetic methodologies and can independently design and execute synthetic procedures.

• Strong written and verbal communication skills to work with interdepartmental teams.

• Ability to multi-task, be efficient and well-organized, and work collaboratively as a team player with high energy in a dynamic and fast-paced environment.

Preferred Skills

• Demonstrated experience in the total synthesis of complex molecules, including multistep route design, synthetic problem-solving, and stereochemical control.

• Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.

• Experience in oncology drug discovery research.

#LI-SB1 #LI-Onsite

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range$119,000—$149,000 USD

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