Convergent Research
Protein Engineer - Biosensing
About this role
Melody, a Pasadena-based nonprofit research organization, seeks a protein engineer to develop innovative biosensors for real-time molecular monitoring. You'll design allosteric protein switches and signal transduction systems, lead wet lab screening, collaborate with hardware teams, and mentor junior scientists while bridging fundamental research with practical device applications.
What you'll do
- Design and engineer biosensor constructs using allosteric switches, linkers, reporter proteins, and chemical modifications
- Establish de novo protein design and directed evolution workflows for internal research operations
- Guide experimental screening campaigns and validate biosensor performance against target analytes
- Partner with hardware engineers to select and optimize protein constructs for device integration
- Mentor junior scientists and manage cross-functional collaboration with academic partners and external vendors
- Integrate device feedback to refine design strategies and improve biosensor development pipeline
What they're looking for
- Protein design (experimental and/or computational approaches)
- Structural biology and biophysics
- Optical and electrophysiological measurement techniques
- Directed evolution and protein selection methods
- Experimental design and scientific project management
- Technical communication across disciplines
- Data analysis and laboratory automation scripting
- Team leadership and cross-functional coordination
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Convergent Research
Convergent Research develops continuous molecular monitoring technology through innovative biosensors and bioelectronics applications. The organization is hiring protein engineers and bioelectronics engineers to design allosteric protein switches, integrate biosensors with hardware, and advance real-world biosensing from lab to in vivo testing.
View all jobs at Convergent ResearchLikely interview questions
- Walk us through a biosensor or protein engineering project where you had to choose between a de novo computational design approach and an experimental-first screening approach. What factors influenced your decision, and what would you do differently?
- Describe your experience designing allosteric protein switches or biosensors. How did you validate that your designs actually responded to the intended stimulus (ion, small molecule, or peptide)?