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Iambic Therapeutics

Machine Learning Scientist — Large Multimodal Models (Post-Training)

Boston Office (Remote)fulltimemidAdded today

About this role

Join Iambic's Enchant team to develop post-training methods for large multimodal foundation models applied to drug discovery. You'll design and evaluate cutting-edge approaches like reinforcement learning and fine-tuning strategies, build scalable training infrastructure, and collaborate across ML, engineering, and chemistry teams to advance therapeutic innovation.

What you'll do

  • Research and develop post-training strategies for multimodal foundation models, including reinforcement learning, fine-tuning, and emerging optimization methods
  • Design reward functions, training objectives, and evaluation protocols for post-training approaches on large-scale LLMs
  • Build experimentation workflows and hyperparameter optimization pipelines for efficient exploration of training recipes and configurations
  • Develop inference optimization techniques and deployment strategies for evaluation and interactive discovery workflows
  • Create and maintain rigorous benchmarking frameworks measuring model quality across modalities, tasks, and drug discovery use cases
  • Collaborate with ML engineers and domain scientists to productionize models and ensure alignment with therapeutic needs

What they're looking for

  • Python and PyTorch
  • Large-scale transformer model training
  • Reinforcement learning (RLHF, RLAIF, PPO, GRPO)
  • Parameter-efficient fine-tuning (LoRA) and supervised fine-tuning
  • Hyperparameter optimization (Optuna, Ray Tune)
  • ML infrastructure (Docker, CUDA, Kubernetes, Weights & Biases)
  • Training and inference optimization (quantization, mixed precision, distributed strategies)
  • Strong software engineering practices and reproducible experimentation
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Iambic Therapeutics

Iambic Therapeutics builds Enchant, a multimodal transformer model designed to accelerate drug discovery through AI-powered clinical prediction and therapeutic decision-making. The company is hiring Machine Learning Scientists to develop and deploy the model, including roles focused on fine-tuning for clinical tasks, building biomedical data pipelines, and advancing model architectures and training at scale.

View all jobs at Iambic Therapeutics

Likely interview questions

  • Walk us through your experience implementing reinforcement learning algorithms like RLHF or PPO. What challenges did you face and how did you overcome them?
  • Describe a project where you trained large-scale transformer models. What optimizations did you use to handle computational constraints?